1494684-28-4
1494684-28-4 structure
- Name: CYH33
- Chemical Name: CYH33
- CAS Number: 1494684-28-4
- Molecular Formula: C24H29F3N8O5S
- Molecular Weight: 598.602
- Catalog: Signaling Pathways PI3K/Akt/mTOR PI3K
- Create Date: 2020-01-12 14:32:50
- Modify Date: 2024-01-04 09:39:18
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CYH33 (CYH-33) is a novel potent, PI3Kα-selective inhibitor with IC50 of 5.9 nM/598 nM/ 78.7 nM/225 nM aginst class I PI3K isoform α/β/δ/γ, respectively; also displays little to no activity against more than 300 kinases; inhibits PI3K/AKT/mTOR signaling in glioblastoma U87MG and rhabdomyosarcoma Rh30 cells, shows potent anti-proliferative activity in against cell proliferation in a panel cancer cell lines originated from breast, lung, ovary and colon, prostate etc.; shows significant efficacy to inhibit the growth of SKOV-3 xenograft. Solid Tumors Phase 1 Clinical
| Name | CYH33 |
|---|
| Description | CYH33 (CYH-33) is a novel potent, PI3Kα-selective inhibitor with IC50 of 5.9 nM/598 nM/ 78.7 nM/225 nM aginst class I PI3K isoform α/β/δ/γ, respectively; also displays little to no activity against more than 300 kinases; inhibits PI3K/AKT/mTOR signaling in glioblastoma U87MG and rhabdomyosarcoma Rh30 cells, shows potent anti-proliferative activity in against cell proliferation in a panel cancer cell lines originated from breast, lung, ovary and colon, prostate etc.; shows significant efficacy to inhibit the growth of SKOV-3 xenograft. Solid Tumors Phase 1 Clinical |
|---|---|
| References | References 1. Haoyue Xiang, et al. Abstract LB-268, AACR, 2018. View Related Products by Target PI3K Solid Tumors |
| Molecular Formula | C24H29F3N8O5S |
|---|---|
| Molecular Weight | 598.602 |