1808011-23-5
1808011-23-5 structure
- Name: EPZ-030456
- Chemical Name: EPZ-030456
- CAS Number: 1808011-23-5
- Molecular Formula: C28H34ClN5O4S
- Molecular Weight: 572.121
- Create Date: 2020-01-20 11:07:56
- Modify Date: 2024-01-18 21:14:05
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EPZ-030456 (EPZ030456) is a potent, selective SMYD3 inhibitor with biochem IC50 of 4 nM; displays noncompetitive inhibition with respect to SAM and MEKK2 with Ki of 1.2 and 1.1 nM, respectively; has cellular potency (IC50=48 nM) suitable to probe the in vitro biology of SMYD3 inhibition.
| Name | EPZ-030456 |
|---|
| Description | EPZ-030456 (EPZ030456) is a potent, selective SMYD3 inhibitor with biochem IC50 of 4 nM; displays noncompetitive inhibition with respect to SAM and MEKK2 with Ki of 1.2 and 1.1 nM, respectively; has cellular potency (IC50=48 nM) suitable to probe the in vitro biology of SMYD3 inhibition. |
|---|---|
| References | References 1. Mitchell LH, et al. ACS Med Chem Lett. 2015 Aug 27;7(2):134-8. View Related Products by Target Histone Methyltransferase (HMTase) |
| Molecular Formula | C28H34ClN5O4S |
|---|---|
| Molecular Weight | 572.121 |