1809427-18-6
1809427-18-6 structure
- Name: SMAP
- Chemical Name: SMAP
- CAS Number: 1809427-18-6
- Molecular Formula: C25H23F3N2O5S
- Molecular Weight: 520.523
- Create Date: 2020-01-12 09:40:51
- Modify Date: 2024-01-14 06:54:11
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SMAP (DT-061, DT061) is an orally bioavailable small molecule activator of PP2A, inhibits KRAS-driven tumor growth; acts by binding to the PP2A Aα scaffold subunit to drive conformational changes in PP2A; inhibits the growth of KRAS-mutant lung cancers in mouse xenografts and transgenic models.
| Name | SMAP |
|---|
| Description | SMAP (DT-061, DT061) is an orally bioavailable small molecule activator of PP2A, inhibits KRAS-driven tumor growth; acts by binding to the PP2A Aα scaffold subunit to drive conformational changes in PP2A; inhibits the growth of KRAS-mutant lung cancers in mouse xenografts and transgenic models. |
|---|---|
| References | References 1. Sangodkar J, et al. J Clin Invest. 2017 Jun 1;127(6):2081-2090. 2. Kauko O, et al. Sci Transl Med. 2018 Jul 18;10(450). pii: eaaq1093. View Related Products by Target Protein Phosphatase/PTP |
| Molecular Formula | C25H23F3N2O5S |
|---|---|
| Molecular Weight | 520.523 |