181141-66-2
181141-66-2 structure
- Name: GGTI-286 dihydrochloride
- Chemical Name: GGTI-286 dihydrochloride
- CAS Number: 181141-66-2
- Molecular Formula: C23H32ClN3O3S
- Molecular Weight: 466.037
- Catalog: Signaling Pathways GPCR/G Protein Ras
- Create Date: 2020-01-20 14:40:57
- Modify Date: 2024-04-02 14:47:28
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GGTI-286 is a CAAX peptidomimetic that is a potent, cell-permeable, and selective inhibitor of GGTase I with IC50 of 2 uM, 25-fold more potent than FTI-277; inhibits processing of the geranylgeranylated protein Rap1A; inhibits oncogenic K-Ras4B stimulation with IC50 of 1 uM; reduces nuclear localization of β-catenin and transcription dependent on β-catenin/T cell factor in mammalian cells; has significant antiproliferative effect in human malignant glioma cells.
| Name | GGTI-286 dihydrochloride |
|---|
| Description | GGTI-286 is a CAAX peptidomimetic that is a potent, cell-permeable, and selective inhibitor of GGTase I with IC50 of 2 uM, 25-fold more potent than FTI-277; inhibits processing of the geranylgeranylated protein Rap1A; inhibits oncogenic K-Ras4B stimulation with IC50 of 1 uM; reduces nuclear localization of β-catenin and transcription dependent on β-catenin/T cell factor in mammalian cells; has significant antiproliferative effect in human malignant glioma cells. |
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| References | References 1. Lerner EC, et al. J Biol Chem. 1995 Nov 10;270(45):26770-3. 2. Nishiya N, et al. Chem Biol. 2014 Apr 24;21(4):530-40. 3. Lerner EC, et al. Oncogene. 1997 Sep;15(11):1283-8. View Related Products by Target Other Targets |
| Molecular Formula | C23H32ClN3O3S |
|---|---|
| Molecular Weight | 466.037 |