1812885-57-6
1812885-57-6 structure
- Name: MNKI-85
- Chemical Name: MNKI-85
- CAS Number: 1812885-57-6
- Molecular Formula: C20H23FN4O3S
- Molecular Weight: 418.487
- Create Date: 2020-01-11 19:14:50
- Modify Date: 2024-09-16 22:11:46
-
MNKI-85 is a potent and selective Mnk2 inhibitor with Ki of 31 nM, displays no inhibitory activities against Mnk1, CDK2A, CDK9T, and CDK4D; effectively inhibits the growth of AML cells that possess an M5 subtype with FLT3-internal tandem duplication mutation, a powerful pharmacologic tool in studying the Mnk2/eIF4E-mediated tumorigenic mechanism.
| Name | MNKI-85 |
|---|
| Description | MNKI-85 is a potent and selective Mnk2 inhibitor with Ki of 31 nM, displays no inhibitory activities against Mnk1, CDK2A, CDK9T, and CDK4D; effectively inhibits the growth of AML cells that possess an M5 subtype with FLT3-internal tandem duplication mutation, a powerful pharmacologic tool in studying the Mnk2/eIF4E-mediated tumorigenic mechanism. |
|---|---|
| References | References 1. Teo T, et al. Mol Pharmacol. 2015 Aug;88(2):380-9. View Related Products by Target MNK |
| Molecular Formula | C20H23FN4O3S |
|---|---|
| Molecular Weight | 418.487 |