2126038-25-1
2126038-25-1 structure
- Name: ST-168
- Chemical Name: ST-168
- CAS Number: 2126038-25-1
- Molecular Formula: C41H44F5IN10O7
- Molecular Weight: 1010.762
- Create Date: 2020-01-11 17:33:50
- Modify Date: 2024-10-22 19:32:36
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ST-168 is a novel potent, orally available MEK/PI3K bifunctional inhibitor with IC50 of 182, 69.2, 1482, 2293, and 41.7 nM for MEK1, PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively; exhibits improved inhibition toward PI3K isoforms compared to ST-162; demonstrates superior tumoricidal efficacy over ST-162 in an A375 melanoma spheroid tumor model.
| Name | ST-168 |
|---|
| Description | ST-168 is a novel potent, orally available MEK/PI3K bifunctional inhibitor with IC50 of 182, 69.2, 1482, 2293, and 41.7 nM for MEK1, PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively; exhibits improved inhibition toward PI3K isoforms compared to ST-162; demonstrates superior tumoricidal efficacy over ST-162 in an A375 melanoma spheroid tumor model. |
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| References | References 1. Van Dort ME, et al. ACS Med Chem Lett. 2017 Jul 24;8(8):808-813. View Related Products by Target PI3K |
| Molecular Formula | C41H44F5IN10O7 |
|---|---|
| Molecular Weight | 1010.762 |