324579-65-9
324579-65-9 structure
- Name: inh-02
- Chemical Name: inh-02
- CAS Number: 324579-65-9
- Molecular Formula: C23H20N4S
- Molecular Weight: 384.501
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2020-01-12 17:45:41
- Modify Date: 2024-04-06 15:40:49
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inh-02 (RNF5 inhibitor inh-02) is a novel small molecule inhibitor of E3 ubiquitin ligase RNF5/RMA1; causes significant F508del-CFTR rescue (EC50=2.2 uM) in immortalized and primary bronchial epithelial cells from CF patients homozygous for the F508del mutation, decreases ubiquitylation of mutant CFTR, causing stabilization of the mature form of CFTR; inh-2 acts on ATG4B and paxillin, which are known targets downstream of RNF5.
| Name | inh-02 |
|---|
| Description | inh-02 (RNF5 inhibitor inh-02) is a novel small molecule inhibitor of E3 ubiquitin ligase RNF5/RMA1; causes significant F508del-CFTR rescue (EC50=2.2 uM) in immortalized and primary bronchial epithelial cells from CF patients homozygous for the F508del mutation, decreases ubiquitylation of mutant CFTR, causing stabilization of the mature form of CFTR; inh-2 acts on ATG4B and paxillin, which are known targets downstream of RNF5. |
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| References | References 1. Sondo E, et al. Cell Chem Biol. 2018 Apr 26. pii: S2451-9456(18)30124-7. View Related Products by Target E3 Ubiquitin Ligase |
| Molecular Formula | C23H20N4S |
|---|---|
| Molecular Weight | 384.501 |