inh-02
Modify Date: 2024-04-06 15:40:49
inh-02 structure
|
Common Name | inh-02 | ||
|---|---|---|---|---|
| CAS Number | 324579-65-9 | Molecular Weight | 384.501 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H20N4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of inh-02inh-02 (RNF5 inhibitor inh-02) is a novel small molecule inhibitor of E3 ubiquitin ligase RNF5/RMA1; causes significant F508del-CFTR rescue (EC50=2.2 uM) in immortalized and primary bronchial epithelial cells from CF patients homozygous for the F508del mutation, decreases ubiquitylation of mutant CFTR, causing stabilization of the mature form of CFTR; inh-2 acts on ATG4B and paxillin, which are known targets downstream of RNF5. |
| Name | inh-02 |
|---|
| Description | inh-02 (RNF5 inhibitor inh-02) is a novel small molecule inhibitor of E3 ubiquitin ligase RNF5/RMA1; causes significant F508del-CFTR rescue (EC50=2.2 uM) in immortalized and primary bronchial epithelial cells from CF patients homozygous for the F508del mutation, decreases ubiquitylation of mutant CFTR, causing stabilization of the mature form of CFTR; inh-2 acts on ATG4B and paxillin, which are known targets downstream of RNF5. |
|---|---|
| References | References 1. Sondo E, et al. Cell Chem Biol. 2018 Apr 26. pii: S2451-9456(18)30124-7. View Related Products by Target E3 Ubiquitin Ligase |
| Molecular Formula | C23H20N4S |
|---|---|
| Molecular Weight | 384.501 |