333742-48-6
333742-48-6 structure
- Name: AZD-8309
- Chemical Name: AZD-8309
- CAS Number: 333742-48-6
- Molecular Formula: C15H14F2N4O2S2
- Molecular Weight: 384.42
- Catalog: Signaling Pathways GPCR/G Protein CXCR
- Create Date: 2020-01-20 11:12:55
- Modify Date: 2024-01-11 16:58:11
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AZD-8309 (AZD8309) is a potent and orally bioavailable CXCR2 antagonist that has been proposed to regulate the transmigration of neutrophils; significantly reduces MPO in the pancreas and lungs, and reduces intrapancreatic trypsin and elastase activity in caerulein-pancreatitis; also reduces cathepsin B activity and MPO in taurocholate-pancreatitis; also antagonises the CCR2b receptor but it is 10-fold less potent than at CXCR2. COPD Phase 1 Clinical
| Name | AZD-8309 |
|---|
| Description | AZD-8309 (AZD8309) is a potent and orally bioavailable CXCR2 antagonist that has been proposed to regulate the transmigration of neutrophils; significantly reduces MPO in the pancreas and lungs, and reduces intrapancreatic trypsin and elastase activity in caerulein-pancreatitis; also reduces cathepsin B activity and MPO in taurocholate-pancreatitis; also antagonises the CCR2b receptor but it is 10-fold less potent than at CXCR2. COPD Phase 1 Clinical |
|---|---|
| References | References 1. Virtala R, et al. Clin Exp Allergy. 2012 Apr;42(4):590-6. 2. Leaker BR, et al. Respir Res. 2013 Dec 16;14:137. 3. Malla SR, et al. Pancreatology. 2016 Sep-Oct;16(5):761-9. View Related Products by Target Chemokine Receptor (CCR and CXCR) COPD |
| Molecular Formula | C15H14F2N4O2S2 |
|---|---|
| Molecular Weight | 384.42 |