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  • DC Chemicals Limited
  • China
  • Product Name: AZD-8309
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

333742-48-6

333742-48-6 structure
333742-48-6 structure
  • Name: AZD-8309
  • Chemical Name: AZD-8309
  • CAS Number: 333742-48-6
  • Molecular Formula: C15H14F2N4O2S2
  • Molecular Weight: 384.42
  • Catalog: Signaling Pathways GPCR/G Protein CXCR
  • Create Date: 2020-01-20 11:12:55
  • Modify Date: 2024-01-11 16:58:11
  • AZD-8309 (AZD8309) is a potent and orally bioavailable CXCR2 antagonist that has been proposed to regulate the transmigration of neutrophils; significantly reduces MPO in the pancreas and lungs, and reduces intrapancreatic trypsin and elastase activity in caerulein-pancreatitis; also reduces cathepsin B activity and MPO in taurocholate-pancreatitis; also antagonises the CCR2b receptor but it is 10-fold less potent than at CXCR2. COPD Phase 1 Clinical

Name AZD-8309
Description AZD-8309 (AZD8309) is a potent and orally bioavailable CXCR2 antagonist that has been proposed to regulate the transmigration of neutrophils; significantly reduces MPO in the pancreas and lungs, and reduces intrapancreatic trypsin and elastase activity in caerulein-pancreatitis; also reduces cathepsin B activity and MPO in taurocholate-pancreatitis; also antagonises the CCR2b receptor but it is 10-fold less potent than at CXCR2. COPD Phase 1 Clinical
References References 1. Virtala R, et al. Clin Exp Allergy. 2012 Apr;42(4):590-6. 2. Leaker BR, et al. Respir Res. 2013 Dec 16;14:137. 3. Malla SR, et al. Pancreatology. 2016 Sep-Oct;16(5):761-9. View Related Products by Target Chemokine Receptor (CCR and CXCR) COPD
Molecular Formula C15H14F2N4O2S2
Molecular Weight 384.42