785708-33-0
785708-33-0 structure
- Name: APA modulator T4
- Chemical Name: APA modulator T4
- CAS Number: 785708-33-0
- Molecular Formula: C22H23N3O3
- Molecular Weight: 377.444
- Create Date: 2020-01-20 18:22:56
- Modify Date: 2024-01-19 17:37:32
-
APA modulator T4 is a small modulator of alternative polyadenylation (APA) with IC50 of 2.1 uM in reporter assays, modulates endogenous APA via nonkinase-mediated pathways and promotes distal-to-proximal (DtoP) APA usage in multiple transcripts; does not inhibits any of the 404 kinases; predominantly induced CR-APA and UTR-APA; APA modulator T4 exhibits high potency and selectivity for APA modulation, inducing a preference for the use of proximal intronic poly(A) CSs with long intron regions through the PABPN1 pathway; APA modulator T4 is a valuable tool for increasing the understanding of the molecular mechanisms of APA and splicing.
| Name | APA modulator T4 |
|---|
| Description | APA modulator T4 is a small modulator of alternative polyadenylation (APA) with IC50 of 2.1 uM in reporter assays, modulates endogenous APA via nonkinase-mediated pathways and promotes distal-to-proximal (DtoP) APA usage in multiple transcripts; does not inhibits any of the 404 kinases; predominantly induced CR-APA and UTR-APA; APA modulator T4 exhibits high potency and selectivity for APA modulation, inducing a preference for the use of proximal intronic poly(A) CSs with long intron regions through the PABPN1 pathway; APA modulator T4 is a valuable tool for increasing the understanding of the molecular mechanisms of APA and splicing. |
|---|---|
| References | References 1. Araki S, et al. Cell Chem Biol. 2018 Sep 26. pii: S2451-9456(18)30301-5. View Related Products by Target Other Targets |
| Molecular Formula | C22H23N3O3 |
|---|---|
| Molecular Weight | 377.444 |