1242422-09-8
1242422-09-8 structure
- Name: SSTC3
- Chemical Name: SSTC3
- CAS Number: 1242422-09-8
- Molecular Formula: C23H17F3N4O3S2
- Molecular Weight: 518.529
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Casein Kinase
- Create Date: 2020-01-11 17:35:51
- Modify Date: 2024-01-20 18:29:49
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SSTC3 is a novel small-molecule CK1α activator with EC50 of 30 nM (WNT-driven reporter gene assay), Kd of 32 nM; has better pharmacokinetic properties than pyrvinium, attenuates the growth of such Apc mutant organoids with EC50 of 2.9 uM; decreases the viability of the WNT-dependent cell lines (EC50 = 132, 63, and 123 nM for HT29, SW403, and HCT116 cells, respectively), inhibits the growth of CRC xenografts in mice; also attenuates the growth of patient-derived metastatic CRC xenograft, with minimal gastrointestinal toxicity compared to other classes of WNT inhibitors.
| Name | SSTC3 |
|---|
| Description | SSTC3 is a novel small-molecule CK1α activator with EC50 of 30 nM (WNT-driven reporter gene assay), Kd of 32 nM; has better pharmacokinetic properties than pyrvinium, attenuates the growth of such Apc mutant organoids with EC50 of 2.9 uM; decreases the viability of the WNT-dependent cell lines (EC50 = 132, 63, and 123 nM for HT29, SW403, and HCT116 cells, respectively), inhibits the growth of CRC xenografts in mice; also attenuates the growth of patient-derived metastatic CRC xenograft, with minimal gastrointestinal toxicity compared to other classes of WNT inhibitors. |
|---|---|
| References | References 1. Li B, et al. Sci Signal. 2017 Jun 27;10(485). pii: eaak9916. View Related Products by Target Casein Kinase |
| Molecular Formula | C23H17F3N4O3S2 |
|---|---|
| Molecular Weight | 518.529 |