1257994-15-2
1257994-15-2 structure
- Name: OXA-11
- Chemical Name: OXA-11
- CAS Number: 1257994-15-2
- Molecular Formula: C37H49F3N7O5P
- Molecular Weight: 759.812
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK FAK
- Create Date: 2020-01-20 00:31:56
- Modify Date: 2024-04-03 08:56:29
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A potent and selective inhibitor of FAK phosphorylation with biochemical IC50 of 1.2 pM (pFAK Y397), cellular IC50 of 1 nM; displays 8-fold selectivity over PYK2, 26-fold selectivity over RSK1/2 , and >1000-fold selectivity over SRC, AURKA, AURKB, INSR, and KDR; suppresses pFAK Y397 and pFAK Y861 in tumors and liver, shows tumor growth inhibition in TOV21G xenografts in mice.
| Name | OXA-11 |
|---|
| Description | A potent and selective inhibitor of FAK phosphorylation with biochemical IC50 of 1.2 pM (pFAK Y397), cellular IC50 of 1 nM; displays 8-fold selectivity over PYK2, 26-fold selectivity over RSK1/2 , and >1000-fold selectivity over SRC, AURKA, AURKB, INSR, and KDR; suppresses pFAK Y397 and pFAK Y861 in tumors and liver, shows tumor growth inhibition in TOV21G xenografts in mice. |
|---|---|
| References | References 1. Moen I, et al. Clin Exp Metastasis. 2015 Dec;32(8):799-817. View Related Products by Target Focal Adhesion Kinase (FAK) |
| Molecular Formula | C37H49F3N7O5P |
|---|---|
| Molecular Weight | 759.812 |