Name | ADAMTS-5 inhibitor 15f |
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Description | ADAMTS-5 inhibitor 15f is a highly potent and selective inhibitor of metalloprotease ADAMTS-5 with IC50 of 30 nM, >50-fold selectivity against ADAMTS-4 and >1000-fold selectivity against ADAMTS-1/13, MMP-13 and TACE; inhibits aggrecanase-mediated (374)ARGS neoepitope release from aggrecan and glycosaminoglycan in response to IL-1β/OSM stimulation. |
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References | References 1. Deng H, et al. J Med Chem. 2012 Aug 23;55(16):7061-79. View Related Products by Target Matrix Metalloproteinase (MMP) |
Molecular Formula | C26H39N9O2S |
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Molecular Weight | 541.719 |