1621673-53-7
1621673-53-7 structure
- Name: KY-226
- Chemical Name: KY-226
- CAS Number: 1621673-53-7
- Molecular Formula: C27H31NO3S2
- Molecular Weight: 481.669
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
- Create Date: 2020-01-11 21:48:51
- Modify Date: 2023-01-14 19:54:13
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KY-226 (KY226) is a potent, allosteric, orally active inhibitor of protein tyrosine phosphatase 1B (PTP1B) with IC50 of 0.28 uM (human PTP1B), does not exhibit PPARγ agonist activity; shows no effects on adipocyte differentiation in rodent preadipocytes at 10 uM, bot not the PPARγ agonist pioglitazone; increases the phosphorylated insulin receptor (pIR) produced by insulin in human hepatoma-derived cells (HepG2) at 0.310 uM, significantly reduces plasma glucose and triglyceride levels as well as hemoglobin A1c values without increasing body weight gain in db/db mice, exerts anti-diabetic and anti-obesity effects by enhancing insulin and leptin signaling.
| Name | KY-226 |
|---|
| Description | KY-226 (KY226) is a potent, allosteric, orally active inhibitor of protein tyrosine phosphatase 1B (PTP1B) with IC50 of 0.28 uM (human PTP1B), does not exhibit PPARγ agonist activity; shows no effects on adipocyte differentiation in rodent preadipocytes at 10 uM, bot not the PPARγ agonist pioglitazone; increases the phosphorylated insulin receptor (pIR) produced by insulin in human hepatoma-derived cells (HepG2) at 0.310 uM, significantly reduces plasma glucose and triglyceride levels as well as hemoglobin A1c values without increasing body weight gain in db/db mice, exerts anti-diabetic and anti-obesity effects by enhancing insulin and leptin signaling. |
|---|---|
| References | References 1. Ito Y, et al. J Pharmacol Sci. 2018 May;137(1):38-46. 2. Sun M, et al. Brain Res. 2018 Sep 1;1694:1-12. View Related Products by Target Protein Phosphatase/PTP |
| Molecular Formula | C27H31NO3S2 |
|---|---|
| Molecular Weight | 481.669 |