1633660-76-0
1633660-76-0 structure
- Name: PNR-7-02
- Chemical Name: PNR-7-02
- CAS Number: 1633660-76-0
- Molecular Formula: C24H16ClN3O2S
- Molecular Weight: 445.921
- Create Date: 2020-01-20 15:00:56
- Modify Date: 2023-01-11 17:02:03
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PNR-7-02 is a specific inhibitor of human DNA Polymerase η (hPol η) with IC50 of 8 uM, exhibits 5-10-fold specificity for hPol η over other replicative Pols; binds to a site on the little finger domain and interferes with the proper orientation of template DNA to inhibit hpol η; potentiates the effects of cisplatin in tumor cells accompanied with increased γH2AX formation.
| Name | PNR-7-02 |
|---|
| Description | PNR-7-02 is a specific inhibitor of human DNA Polymerase η (hPol η) with IC50 of 8 uM, exhibits 5-10-fold specificity for hPol η over other replicative Pols; binds to a site on the little finger domain and interferes with the proper orientation of template DNA to inhibit hpol η; potentiates the effects of cisplatin in tumor cells accompanied with increased γH2AX formation. |
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| References | References 1. Zafar MK, et al. Biochemistry. 2018 Feb 20;57(7):1262-1273. View Related Products by Target DNA/RNA Synthesis |
| Molecular Formula | C24H16ClN3O2S |
|---|---|
| Molecular Weight | 445.921 |