1803427-24-8

1803427-24-8 structure

Name: CK2 inhibitor D11
Chemical Name: D11
CAS Number: 1803427-24-8
Molecular Formula: C₂₀H₁₃Cl₂NO₄
Molecular Weight: 402.227
Create Date: 2020-01-11 20:20:49
Modify Date: 2024-02-03 14:14:24
A potent, selective, cell permeab anti-apoptotic protein kinase CK2 with Ki of 5 nM; potently inhibits CK2α with IC50 of 7 nM, shows <2% remaining kinase activity against a panel of 354 eukaryotic protein kinases with exception of DYRK1B, PIM3 and IRAK1 (IC50=20-50 nM); inhibits the phosphorylation of the CK2 biomarker CDC37 at S13 in MIA PaCa-2 cells, also inhibits S380/T382/383 phosphorylation in PTEN in NSCLC cells.

Name	D11

Description	A potent, selective, cell permeab anti-apoptotic protein kinase CK2 with Ki of 5 nM; potently inhibits CK2α with IC50 of 7 nM, shows <2% remaining kinase activity against a panel of 354 eukaryotic protein kinases with exception of DYRK1B, PIM3 and IRAK1 (IC50=20-50 nM); inhibits the phosphorylation of the CK2 biomarker CDC37 at S13 in MIA PaCa-2 cells, also inhibits S380/T382/383 phosphorylation in PTEN in NSCLC cells.
References	References 1. Guerra B, et al. Mol Cell Biochem. 2015 Aug;406(1-2):151-61. View Related Products by Target Casein Kinase

Molecular Formula	C₂₀H₁₃Cl₂NO₄
Molecular Weight	402.227