2040055-84-1
2040055-84-1 structure
- Name: PF-4363467
- Chemical Name: PF-4363467
- CAS Number: 2040055-84-1
- Molecular Formula: C22H30N2O3S
- Molecular Weight: 402.553
- Create Date: 2020-01-11 21:50:50
- Modify Date: 2024-10-02 11:15:49
-
PF-4363467 (PF 04363467) is a novel highly potent, brain penetrant dopamine D3/D2 receptor antagonist with Ki of 1.3/692 nM respectively, with high selectivity for D3R versus other biogenic amine receptors; dose-dependently attenuated opioid self-administration and opioid drug-seeking behavior in a rat operant reinstatement model using animals trained to self-administer fentanyl.
| Name | PF-4363467 |
|---|
| Description | PF-4363467 (PF 04363467) is a novel highly potent, brain penetrant dopamine D3/D2 receptor antagonist with Ki of 1.3/692 nM respectively, with high selectivity for D3R versus other biogenic amine receptors; dose-dependently attenuated opioid self-administration and opioid drug-seeking behavior in a rat operant reinstatement model using animals trained to self-administer fentanyl. |
|---|---|
| References | References 1. Wager TT, et al. ACS Chem Neurosci. 2017 Jan 18;8(1):165-177. View Related Products by Target Dopamine Receptor |
| Molecular Formula | C22H30N2O3S |
|---|---|
| Molecular Weight | 402.553 |