2052301-24-1
2052301-24-1 structure
- Name: BTX161
- Chemical Name: BTX161
- CAS Number: 2052301-24-1
- Molecular Formula: C15H16N2O3
- Molecular Weight: 272.304
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Casein Kinase
- Create Date: 2020-01-11 16:53:49
- Modify Date: 2024-01-09 18:28:20
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BTX161 is a thalidomide analog that mediates degradation of CKIα better than lenalidomide in human AML cells and activates DDR and p53, while stabilizing the p53 antagonist MDM2; upregulates all the Wnt targets including MYC and does not affect MDM2 mRNA expression.
| Name | BTX161 |
|---|
| Description | BTX161 is a thalidomide analog that mediates degradation of CKIα better than lenalidomide in human AML cells and activates DDR and p53, while stabilizing the p53 antagonist MDM2; upregulates all the Wnt targets including MYC and does not affect MDM2 mRNA expression. |
|---|---|
| References | References 1. Minzel W, et al. Cell. 2018 Aug 20. pii: S0092-8674(18)30973-5. doi: 10.1016/j.cell.2018.07.045. View Related Products by Target Casein Kinase |
| Molecular Formula | C15H16N2O3 |
|---|---|
| Molecular Weight | 272.304 |