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  • DC Chemicals Limited
  • China
  • Product Name: BRD3731
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

2056262-08-7

2056262-08-7 structure
2056262-08-7 structure
  • Name: BRD3731
  • Chemical Name: BRD3731
  • CAS Number: 2056262-08-7
  • Molecular Formula: C24H31N3O
  • Molecular Weight: 377.532
  • Catalog: Signaling Pathways PI3K/Akt/mTOR GSK-3
  • Create Date: 2020-01-20 18:40:56
  • Modify Date: 2024-04-02 04:54:30
  • BRD3731 is a potent, selective GSK3β inhibitor with IC50 of 15 nM, 14-fold selectivity for GSK3β over GSK3α (IC50=215 nM); displays excellent selectivity in a penal of 311 kinases, displays reduced potency toward the GSK3β mutant (D133E) with IC50 of 53 nM; induces β-catenin stabilization starting at 20 uM in the HL-60 AML cell line, decreases β-catenin S33/37/T41 phosphorylation and induces β-catenin S675 phosphorylation, resulting in increased β-catenin.

Name BRD3731
Description BRD3731 is a potent, selective GSK3β inhibitor with IC50 of 15 nM, 14-fold selectivity for GSK3β over GSK3α (IC50=215 nM); displays excellent selectivity in a penal of 311 kinases, displays reduced potency toward the GSK3β mutant (D133E) with IC50 of 53 nM; induces β-catenin stabilization starting at 20 uM in the HL-60 AML cell line, decreases β-catenin S33/37/T41 phosphorylation and induces β-catenin S675 phosphorylation, resulting in increased β-catenin.
References References 1. Wagner FF, et al. Sci Transl Med. 2018 Mar 7;10(431). pii: eaam8460. View Related Products by Target GSK-3
Molecular Formula C24H31N3O
Molecular Weight 377.532