2137044-49-4

2137044-49-4 structure

Name: LSD1-IN-32
Chemical Name: LSD1-IN-32
CAS Number: 2137044-49-4
Molecular Formula: C₂₄H₂₇FN₄O₂
Molecular Weight: 422.504
Create Date: 2020-01-12 11:39:45
Modify Date: 2024-04-04 19:34:22
LSD1-IN-32 is a potent, reversible lysine specific demethylase 1 (LSD1) inhibitor with biochemical IC50 of 83 nM, Kd of 32 nM, cell EC50 of 0.67 uM; display much greater levels of selectivity over the hERG cardiac ion channel than GSK-690; shows significant anti-proliferative activity, promotes the differentiation of AML cells, with concomitant reduction in clonogenic potential.

Name	LSD1-IN-32

Description	LSD1-IN-32 is a potent, reversible lysine specific demethylase 1 (LSD1) inhibitor with biochemical IC50 of 83 nM, Kd of 32 nM, cell EC50 of 0.67 uM; display much greater levels of selectivity over the hERG cardiac ion channel than GSK-690; shows significant anti-proliferative activity, promotes the differentiation of AML cells, with concomitant reduction in clonogenic potential.
References	References 1. Mould DP, et al. J Med Chem. 2017 Oct 12;60(19):7984-7999. View Related Products by Target Histone Demethylase

Molecular Formula	C₂₄H₂₇FN₄O₂
Molecular Weight	422.504