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2230640-94-3

2230640-94-3 structure
2230640-94-3 structure
  • Name: TT-10
  • Chemical Name: TT-10
  • CAS Number: 2230640-94-3
  • Molecular Formula: C11H10FN3OS2
  • Molecular Weight: 283.339
  • Catalog: Signaling Pathways Stem Cell/Wnt YAP
  • Create Date: 2020-01-19 17:30:27
  • Modify Date: 2024-01-04 07:02:52
  • TT-10 (YAP-TEAD activator TT-10) is a small molecule activator that activates pro-proliferative YES-associated protein (YAP) and transcriptional enhancer factor domain (TEAD) activities in cardiomyocytes; promoted cardiomyocyte proliferation and simultaneously exerted antioxidant and antiapoptotic effects in vitro via nuclear translocation of YAP, activates YAP-TEADs activity and the Wnt/β-Catenin signaling pathway; ameliorates cardiac dysfunction, decreases ROS and DNA aamage and apoptosis after myocardial infarction (MI) in mice.

Name TT-10
Description TT-10 (YAP-TEAD activator TT-10) is a small molecule activator that activates pro-proliferative YES-associated protein (YAP) and transcriptional enhancer factor domain (TEAD) activities in cardiomyocytes; promoted cardiomyocyte proliferation and simultaneously exerted antioxidant and antiapoptotic effects in vitro via nuclear translocation of YAP, activates YAP-TEADs activity and the Wnt/β-Catenin signaling pathway; ameliorates cardiac dysfunction, decreases ROS and DNA aamage and apoptosis after myocardial infarction (MI) in mice.
References References 1. Hara H, et al. JACC Basic Transl Sci. 2018 Nov 12;3(5):639-653. View Related Products by Target Yes-associated Protein (YAP)
Molecular Formula C11H10FN3OS2
Molecular Weight 283.339