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681282-09-7

681282-09-7 structure
681282-09-7 structure
  • Name: MYCMI-6(NSC 354961)
  • Chemical Name: MYCMI-6
  • CAS Number: 681282-09-7
  • Molecular Formula: C20H19N7O
  • Molecular Weight: 373.42
  • Catalog: Signaling Pathways Apoptosis Apoptosis
  • Create Date: 2020-01-20 12:07:56
  • Modify Date: 2024-09-16 09:47:27
  • MYCMI-6 (NSC354961) is a selective, high affinity inhibitor of MYC-MAX interaction, blocks MYC-driven transcription and binds selectively to the MYC bHLHZip domain with Kd of 1.6 uM in SPR assay; specifcally targets MYC:MAX interaction without interfering with other MYC activities, selectively suppresses MYC-driven tumor cell growth with high efficacy, efficiently inhibits anchorage-independent growth of MYCN-amplifed neuroblastoma cells with GI50 values of <0.4, 5 and 0.75 μM, respectively; reduces proliferation and induces massive apoptosis in tumor tissue from a MYC-driven xenograft tumor model without severe side effects

Name MYCMI-6
Description MYCMI-6 (NSC354961) is a selective, high affinity inhibitor of MYC-MAX interaction, blocks MYC-driven transcription and binds selectively to the MYC bHLHZip domain with Kd of 1.6 uM in SPR assay; specifcally targets MYC:MAX interaction without interfering with other MYC activities, selectively suppresses MYC-driven tumor cell growth with high efficacy, efficiently inhibits anchorage-independent growth of MYCN-amplifed neuroblastoma cells with GI50 values of <0.4, 5 and 0.75 μM, respectively; reduces proliferation and induces massive apoptosis in tumor tissue from a MYC-driven xenograft tumor model without severe side effects
References References 1. Castell A, et al. Sci Rep. 2018 Jul 3;8(1):10064. View Related Products by Target c-Myc
Molecular Formula C20H19N7O
Molecular Weight 373.42
Hazard Codes Xi