932705-04-9

932705-04-9 structure

Name: MK-1925
Chemical Name: MK-1925
CAS Number: 932705-04-9
Molecular Formula: C₁₉H₂₁F₃N₄
Molecular Weight: 362.4
Create Date: 2020-01-12 14:24:50
Modify Date: 2024-04-04 15:47:54
MK-1925 is a selective, orally active, brain-penetrant opioid receptor-like 1 (ORL1;NOP receptor) antagonist with binding IC50 of 8.2 nM; shows good selectivity over other opioid receptors and the hERG channel; exhibits in vivo antagonist activity against the reduction in locomotor activity induced by ORL1 agonist in mice.

Name	MK-1925

Description	MK-1925 is a selective, orally active, brain-penetrant opioid receptor-like 1 (ORL1;NOP receptor) antagonist with binding IC50 of 8.2 nM; shows good selectivity over other opioid receptors and the hERG channel; exhibits in vivo antagonist activity against the reduction in locomotor activity induced by ORL1 agonist in mice.
References	References 1. Kobayashi K, et al. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4729-32. View Related Products by Target Opioid Receptor

Molecular Formula	C₁₉H₂₁F₃N₄
Molecular Weight	362.4