946594-19-0

946594-19-0 structure

Name: BMS-457
Chemical Name: BMS-457
CAS Number: 946594-19-0
Molecular Formula: C₂₄H₃₅ClN₂O₄
Molecular Weight: 451.004
Create Date: 2020-01-20 11:58:55
Modify Date: 2024-09-06 16:21:53
BMS-457 is a potent and selective CCR1 antagonist with binding IC50 of 0.8 nM, >1,000-fold selectivity against other CC family receptors; displays single-digit nanomolar inhibition of chemotaxis induced by a number of CCR1 ligands, including MIP-1α( IC50=2.1 nM), Leukotactin-1 (IC50=4.4 nM), RANTES (IC50=1.0 nM), MPIF-1 (IC50=2.7 nM), and HCC-1 (IC50=4.0 nM); blocks the ligand-stimulated upregulation of the β2-integrin CD11b in whole blood, with IC50 of 46 nM (MIP-1α) and 54 nM (LKN-1).

Name	BMS-457

Description	BMS-457 is a potent and selective CCR1 antagonist with binding IC50 of 0.8 nM, >1,000-fold selectivity against other CC family receptors; displays single-digit nanomolar inhibition of chemotaxis induced by a number of CCR1 ligands, including MIP-1α( IC50=2.1 nM), Leukotactin-1 (IC50=4.4 nM), RANTES (IC50=1.0 nM), MPIF-1 (IC50=2.7 nM), and HCC-1 (IC50=4.0 nM); blocks the ligand-stimulated upregulation of the β2-integrin CD11b in whole blood, with IC50 of 46 nM (MIP-1α) and 54 nM (LKN-1).
References	References 1. Gardner DS, et al. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3833-40. View Related Products by Target Chemokine Receptor (CCR and CXCR)

Molecular Formula	C₂₄H₃₅ClN₂O₄
Molecular Weight	451.004