946594-19-0
946594-19-0 structure
- Name: BMS-457
- Chemical Name: BMS-457
- CAS Number: 946594-19-0
- Molecular Formula: C24H35ClN2O4
- Molecular Weight: 451.004
- Create Date: 2020-01-20 11:58:55
- Modify Date: 2024-09-06 16:21:53
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BMS-457 is a potent and selective CCR1 antagonist with binding IC50 of 0.8 nM, >1,000-fold selectivity against other CC family receptors; displays single-digit nanomolar inhibition of chemotaxis induced by a number of CCR1 ligands, including MIP-1α( IC50=2.1 nM), Leukotactin-1 (IC50=4.4 nM), RANTES (IC50=1.0 nM), MPIF-1 (IC50=2.7 nM), and HCC-1 (IC50=4.0 nM); blocks the ligand-stimulated upregulation of the β2-integrin CD11b in whole blood, with IC50 of 46 nM (MIP-1α) and 54 nM (LKN-1).
| Name | BMS-457 |
|---|
| Description | BMS-457 is a potent and selective CCR1 antagonist with binding IC50 of 0.8 nM, >1,000-fold selectivity against other CC family receptors; displays single-digit nanomolar inhibition of chemotaxis induced by a number of CCR1 ligands, including MIP-1α( IC50=2.1 nM), Leukotactin-1 (IC50=4.4 nM), RANTES (IC50=1.0 nM), MPIF-1 (IC50=2.7 nM), and HCC-1 (IC50=4.0 nM); blocks the ligand-stimulated upregulation of the β2-integrin CD11b in whole blood, with IC50 of 46 nM (MIP-1α) and 54 nM (LKN-1). |
|---|---|
| References | References 1. Gardner DS, et al. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3833-40. View Related Products by Target Chemokine Receptor (CCR and CXCR) |
| Molecular Formula | C24H35ClN2O4 |
|---|---|
| Molecular Weight | 451.004 |