2079892-79-6

2079892-79-6 structure
2079892-79-6 structure
  • Name: RORγt inhibitor 1
  • Chemical Name: RORγt inhibitor 1
  • CAS Number: 2079892-79-6
  • Molecular Formula: C26H33N7O2
  • Molecular Weight: 475.597
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease ROR
  • Create Date: 2020-01-13 23:54:08
  • Modify Date: 2024-01-14 19:15:32
  • A potent, selective, orally bioavailable RORγt inverse agonist with IC50 of 17 nM in TR-FRET assays; shows no inhibitory activity against the closely related nuclear hormone receptors RORα or RORβ; attenuates expression of genes such as IL26, IL23R and CCR6 in primary human Th17 cells, attenuate the knee swelling response in an antigen-induced arthritis rat models and inhibits IL-17A cytokine production in ex vivo recall assays.

Name RORγt inhibitor 1
Description A potent, selective, orally bioavailable RORγt inverse agonist with IC50 of 17 nM in TR-FRET assays; shows no inhibitory activity against the closely related nuclear hormone receptors RORα or RORβ; attenuates expression of genes such as IL26, IL23R and CCR6 in primary human Th17 cells, attenuate the knee swelling response in an antigen-induced arthritis rat models and inhibits IL-17A cytokine production in ex vivo recall assays.
References References 1. Guendisch U, et al. PLoS One. 2017 Nov 20;12(11):e0188391. 2. Hintermann S, et al. ChemMedChem. 2016 Dec 16;11(24):2640-2648. View Related Products by Target ROR
Molecular Formula C26H33N7O2
Molecular Weight 475.597