Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Pam3CSK4 TFA
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Huang

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Pam3CSK4 TFA
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai

DC Chemicals Limited
China
Product Name: Pam3CSK4 TFA
Price: $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

112208-01-2

112208-01-2 structure

112208-01-2 structure

Name: Pam3CSK4 TFA
Chemical Name: Pam3CSK4 TFA
CAS Number: 112208-01-2
Molecular Formula: C₈₇H₁₅₉F₉N₁₀O₁₉S
Molecular Weight: 1852.33
Catalog: Signaling Pathways Immunology/Inflammation Toll-like Receptor (TLR)
Create Date: 2020-01-23 09:22:51
Modify Date: 2024-01-02 16:14:40
Pam3CSK4 TFA is a toll-like receptor 1/2 (TLR1/2) agonist with an EC50 of 0.47 ng/mL for human TLR1/2[1].

Name	Pam3CSK4 TFA

Description	Pam3CSK4 TFA is a toll-like receptor 1/2 (TLR1/2) agonist with an EC50 of 0.47 ng/mL for human TLR1/2[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR) Research Areas >> Infection Research Areas >> Inflammation/Immunology
In Vitro	Pam3CSK4 is a TLR1/2 heterodimer recognises triacylated lipopeptides[1]. Pam3CSK4 (1 μg/mL) enhances the antibacterial functions of granulocyte macrophage-colony stimulating factor (GM-CSF) induced neutrophils to Methicillin-resistant Staphylococcus aureus (MRSA)[2].
In Vivo	Pam3CSK4 (5 mg/kg; i.p.; once a day for 9 days) alters brain, spleen and liver weights in neonatal mice[3]. Animal Model: Time-mated pregnant C57BL/6 wild-type mice; B6.129-Tlr2tm1Kir/J (TLR2 -deficient) mice[3] Dosage: 5 mg/kg Administration: Intraperitoneally (i.p.); once a day for 9 days Result: After repeated administration from postnatal day (PND3) to PND11, brain weight was decreased compared with endotoxin-free saline-treated animals at PND12. Decreased volume of cerebral gray matter, white matter in the forebrain and cerebellar molecular layer that was accompanied by an increase in spleen and liver weight at PND12.
References	[1]. Irvine KL, et al. The molecular basis for recognition of bacterial ligands at equine TLR2, TLR1 and TLR6. Vet Res. 2013 Jul 4;44:50. [2]. Chen Y, et al. TLR2 agonist Pam3CSK4 enhances the antibacterial functions of GM-CSF induced neutrophils to methicillin-resistant Staphylococcus aureus. Microb Pathog. 2019 May;130:204-212. [3]. Du X, et al. Systemic stimulation of TLR2 impairs neonatal mouse brain development. PLoS One. 2011 May 6;6(5):e19583.

Molecular Formula	C₈₇H₁₅₉F₉N₁₀O₁₉S
Molecular Weight	1852.33