Shanghai Nianxing Industrial Co., Ltd
China
Product Name: TD-165
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Huang

DC Chemicals Limited
China
Product Name: TD-165
Price: ￥900.0/100mg ￥1650.0/250mg ￥2900.0/1g
Purity: 98.0%
Stocking Period: 1 Day
Contact: Tony Cao

2305936-56-3

2305936-56-3 structure

2305936-56-3 structure

Name: TD-165
Chemical Name: TD-165
CAS Number: 2305936-56-3
Molecular Formula: C₄₆H₅₉N₇O₈S
Molecular Weight: 870.07
Catalog: Signaling Pathways PROTAC PROTAC
Create Date: 2020-01-23 19:06:51
Modify Date: 2024-01-21 07:10:18
TD-165 is a cereblon (CRBN) degrader. TD-165comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group[1].

Name	TD-165

Description	TD-165 is a cereblon (CRBN) degrader. TD-165comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC
Target	Cereblon:20.4 nM (DC50)
In Vitro	TD-165 (0-100 nM; 24 hours) shows 50% degradation concentration (DC50) and maximum degradation (Dmax) value of 20.4 nM and 99.6%, respectively[1]. TD-165 (0.1-10 μM; 24 hours) lead to a concentration-dependent decrease in the level of CRBN proteins in HEK293T cells[1]. Cell Viability Assay[1] Cell Line: HEK293T cells Concentration: 0-100 nM Incubation Time: 24 hours Result: Exhibited an DC50 value of 20.4 nM. Western Blot Analysis[1] Cell Line: HEK293T cells Concentration: 0.1, 1, and 10 μM Incubation Time: 24 hours Result: Decreased the level of CRBN protein.
References	[1]. Kim K, et al. Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera.Sci Rep. 2019 Dec 23;9(1):19654.

Molecular Formula	C₄₆H₅₉N₇O₈S
Molecular Weight	870.07

Hazard Codes	Xi