9054-84-6
9054-84-6 structure
- Name: xanthine dehydrogenase
- Chemical Name: xanthine dehydrogenase
- CAS Number: 9054-84-6
- Molecular Formula:
- Molecular Weight:
- Create Date: 2020-03-30 07:15:13
- Modify Date: 2024-01-06 11:50:27
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Acts on a variety of purines and aldehydes, including hypoxanthine. The mammalian enzyme can also convert all-trans retinol to all-trans-retinoate, while the substrate is bound to a retinoid-binding protein. The enzyme from eukaryotes contains [2Fe-2S], FAD and a molybdenum centre. The mammalian enzyme predominantly exists as the NAD-dependent dehydrogenase (EC 1.17.1.4). During purification the enzyme is largely converted to an O2-dependent form, xanthine oxidase (EC 1.17.3.2). The conversion can be triggered by several mechanisms, including the oxidation of cysteine thiols to form disulfide bonds [which can be catalysed by EC 1.8.4.7, enzyme-thiol transhydrogenase (glutathione-disulfide) in the presence of glutathione disulfide] or limited proteolysis, which results in irreversible conversion. The conversion can also occur in vivo. Reaction: xanthine + NAD+ + H2O = urate + NADH + H+
| Name | xanthine dehydrogenase |
|---|---|
| Synonyms |
EC 1.17.1.4
NAD+-xanthine dehydrogenase xanthine-NAD+ oxidoreductase xanthine/NAD+ oxidoreductase xanthine oxidoreductase |
| Description | Acts on a variety of purines and aldehydes, including hypoxanthine. The mammalian enzyme can also convert all-trans retinol to all-trans-retinoate, while the substrate is bound to a retinoid-binding protein. The enzyme from eukaryotes contains [2Fe-2S], FAD and a molybdenum centre. The mammalian enzyme predominantly exists as the NAD-dependent dehydrogenase (EC 1.17.1.4). During purification the enzyme is largely converted to an O2-dependent form, xanthine oxidase (EC 1.17.3.2). The conversion can be triggered by several mechanisms, including the oxidation of cysteine thiols to form disulfide bonds [which can be catalysed by EC 1.8.4.7, enzyme-thiol transhydrogenase (glutathione-disulfide) in the presence of glutathione disulfide] or limited proteolysis, which results in irreversible conversion. The conversion can also occur in vivo. Reaction: xanthine + NAD+ + H2O = urate + NADH + H+ |
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| No Any Chemical & Physical Properties |