1026652-90-3

1026652-90-3 structure
1026652-90-3 structure
  • Name: Xanthine oxidoreductase-IN-5
  • Chemical Name: Xanthine oxidoreductase-IN-5
  • CAS Number: 1026652-90-3
  • Molecular Formula: C17H17N5O2
  • Molecular Weight: 323.35
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease Xanthine Oxidase
  • Create Date: 2023-01-15 03:35:18
  • Modify Date: 2024-04-06 09:15:25
  • Xanthine oxidoreductase-IN-5 is an orally active xanthine oxidoreductase (XOR) inhibitor, with an IC50 of 55 nM. Xanthine oxidoreductase-IN-5 can be used for the research of acute hyperuricemia[1].

Name Xanthine oxidoreductase-IN-5
Description Xanthine oxidoreductase-IN-5 is an orally active xanthine oxidoreductase (XOR) inhibitor, with an IC50 of 55 nM. Xanthine oxidoreductase-IN-5 can be used for the research of acute hyperuricemia[1].
Related Catalog
Target

IC50: 55 nM (xanthine oxidoreductase)[1]

In Vivo Xanthine oxidoreductase-IN-5 (化合物 IIIa) (5 mg/kg; 口服给药) 在给药后 5 h 显示出降低急性高尿酸血症小鼠尿酸的作用[1]。 Animal Model: ICR mice (18-22 g) were induced acute hyperuricemia by injection of potassium oxonate and hypoxanthine[1] Dosage: 5 mg/kg Administration: Suspended in 0.5% CMC-Na solution for intragastric administration Result: Showed a uric acid-lowering effect from 5 h after administration.
References

[1]. Peng W, et, al. Design, synthesis, and evaluation of tricyclic compounds containing phenyl-tetrazole as XOR inhibitors. Eur J Med Chem. 2022 Nov 28;246:114947.  

Molecular Formula C17H17N5O2
Molecular Weight 323.35