Name | Xanthine oxidoreductase-IN-5 |
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Description | Xanthine oxidoreductase-IN-5 is an orally active xanthine oxidoreductase (XOR) inhibitor, with an IC50 of 55 nM. Xanthine oxidoreductase-IN-5 can be used for the research of acute hyperuricemia[1]. |
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Related Catalog | |
Target |
IC50: 55 nM (xanthine oxidoreductase)[1] |
In Vivo | Xanthine oxidoreductase-IN-5 (化合物 IIIa) (5 mg/kg; 口服给药) 在给药后 5 h 显示出降低急性高尿酸血症小鼠尿酸的作用[1]。 Animal Model: ICR mice (18-22 g) were induced acute hyperuricemia by injection of potassium oxonate and hypoxanthine[1] Dosage: 5 mg/kg Administration: Suspended in 0.5% CMC-Na solution for intragastric administration Result: Showed a uric acid-lowering effect from 5 h after administration. |
References |
Molecular Formula | C17H17N5O2 |
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Molecular Weight | 323.35 |