2819989-61-0
2819989-61-0 structure
- Name: PBRM1-BD2-IN-5
- Chemical Name: PBRM1-BD2-IN-5
- CAS Number: 2819989-61-0
- Molecular Formula: C15H13ClN2O
- Molecular Weight: 272.73
- Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
- Create Date: 2022-11-27 17:11:53
- Modify Date: 2024-04-05 13:30:13
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PBRM1-BD2-IN-5 is a potent PBRM1 Bromodomain inhibitor with Kd values of 1.5 μM and 3.9 μM for PBRM1-BD2 and PBRM1-BD5, respectively, and an IC50 value of 0.26 μM for PBRM1-BD2. PBRM1-BD2-IN-5 reduces the binding of full-length PBRM1 within the PBAF complex in cell lysates to acetylated histone peptide. PBRM1-BD2-IN-5 can be used to research anticancer[1].
| Name | PBRM1-BD2-IN-5 |
|---|
| Description | PBRM1-BD2-IN-5 is a potent PBRM1 Bromodomain inhibitor with Kd values of 1.5 μM and 3.9 μM for PBRM1-BD2 and PBRM1-BD5, respectively, and an IC50 value of 0.26 μM for PBRM1-BD2. PBRM1-BD2-IN-5 reduces the binding of full-length PBRM1 within the PBAF complex in cell lysates to acetylated histone peptide. PBRM1-BD2-IN-5 can be used to research anticancer[1]. |
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| Related Catalog | |
| Target |
Kd: 1.5 μM (PBRM1-BD2), 3.9 μM (PBRM1-BD5)[1] IC50: 0.26 μM (PBRM1-BD2)[1] |
| In Vitro | PBRM1-BD2-IN-5 (compound 16) (0-10 μM; 5 days) inhibits PBRM1-expressed LNCaP cells, and reduces the binding of full-length PBRM1 within the PBAF complex in cell lysates to acetylated histone peptides[1]. Cell Viability Assay[1] Cell Line: LNCaP cells expressing lentiviral shPBRM1 Concentration: 0, 0.1, 1 and 10 μM Incubation Time: 5 days Result: Exhibited a more significant effect on LNCaP viability in cells with native PBRM1 levels than in cells with PBRM1 knockdown. Reduced the binding of full-length PBRM1 within the PBAF complex in cell lysates to acetylated histone peptides. |
| Molecular Formula | C15H13ClN2O |
|---|---|
| Molecular Weight | 272.73 |