2819989-75-6

2819989-75-6 structure
2819989-75-6 structure
  • Name: PBRM1-BD2-IN-8
  • Chemical Name: PBRM1-BD2-IN-8
  • CAS Number: 2819989-75-6
  • Molecular Formula: C15H13BrN2O
  • Molecular Weight: 317.18
  • Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
  • Create Date: 2022-11-27 07:02:20
  • Modify Date: 2024-04-12 18:52:33
  • PBRM1-BD2-IN-8 (compound 34) is a potent PBRM1 Bromodomain inhibitor (PBRM1-BD2 Kd=4.4 μM, PBRM1-BD2 IC50=0.16 μM; PBRM1-BD5 Kd=25 μM). PBRM1-BD2-IN-8 shows anti-cancer activity[1].

Name PBRM1-BD2-IN-8
Description PBRM1-BD2-IN-8 (compound 34) is a potent PBRM1 Bromodomain inhibitor (PBRM1-BD2 Kd=4.4 μM, PBRM1-BD2 IC50=0.16 μM; PBRM1-BD5 Kd=25 μM). PBRM1-BD2-IN-8 shows anti-cancer activity[1].
Related Catalog
Target

IC50: 0.16 μM (PBRM1-BD2)[1]

In Vitro PBRM1-BD2-IN-8 (0-100 μM; 48 h) inhibits the growth of PBRM1-dependent prostate cancer cells[1]. Cell Viability Assay[1] Cell Line: LNCaP cells Concentration: 0-100 μM Incubation Time: 48 hours Result: Inhibited the growth of LNCaP cells with IC50 value of about 9 μM.
Molecular Formula C15H13BrN2O
Molecular Weight 317.18