888958-25-6

888958-25-6 structure

Name: SARS-CoV-IN-1
Chemical Name: SARS-CoV-IN-1
CAS Number: 888958-25-6
Molecular Formula: C₂₃H₁₆ClFeN₃O
Molecular Weight: 441.69
Catalog: Signaling Pathways Anti-infection SARS-CoV
Create Date: 2020-04-10 09:04:26
Modify Date: 2024-01-09 17:32:56
SARS-CoV-IN-1 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-1 shows anti-Coronavirus activity with an EC50 of 4.9 μM in Vero cells. SARS-CoV-IN-1 inhibits the 3D7 and W2 strains of P. falciparum with IC50s of 15.4 and 133.2 nM; and IC90s of 25.7 and 459.1 nM; respectively. Antimalarial and antiviral activities[1].

Name	SARS-CoV-IN-1

Description	SARS-CoV-IN-1 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-1 shows anti-Coronavirus activity with an EC50 of 4.9 μM in Vero cells. SARS-CoV-IN-1 inhibits the 3D7 and W2 strains of P. falciparum with IC50s of 15.4 and 133.2 nM; and IC90s of 25.7 and 459.1 nM; respectively. Antimalarial and antiviral activities[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV
Target	EC50: 4.9 μM (SARS-CoV, in Vero cells)[1] IC50: 15.4 nM (3D7 P. falciparum), 133.2 nM (W2 P. falciparum)[1] IC90: 25.7 nM (3D7 P. falciparum), 459.1 nM (W2 P. falciparum)[1]
In Vitro	SARS-CoV-IN-1 (Compound 2) inhibits in vitro growth of Plasmodium falciparum far better than Chloroquine (CQ) [1].
References	[1]. Biot C, et al. Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities. J Med Chem. 2006 May 4;49(9):2845-9.

Molecular Formula	C₂₃H₁₆ClFeN₃O
Molecular Weight	441.69