1422253-37-9

1422253-37-9 structure

Name: C-82
Chemical Name: C-82
CAS Number: 1422253-37-9
Molecular Formula: C₃₃H₃₄N₆O₄
Molecular Weight: 578.66
Catalog: Signaling Pathways Stem Cell/Wnt Wnt
Create Date: 2020-06-01 19:00:55
Modify Date: 2024-01-03 15:01:47
C-82 is a second-generation specific CBP/β-catenin antagonist, which inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300.

Name	C-82

Description	C-82 is a second-generation specific CBP/β-catenin antagonist, which inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Stem Cell/Wnt >> Wnt
Target	CBP/β-catenin[1]
In Vitro	C-82 is an active form of PRI-724. C-82 inhibits the activation of isolated primary mouse quiescent hepatic stellate cells (HSCs) and promotes cell death in culture-activated HSCs[1].
In Vivo	PRI-724 is phosphorylated-C-82 and is rapidly hydrolyzed to its active form C-82 in vivo, and pre-clinical studies have shown a very acceptable toxicity profile[1].
Cell Assay	The culture-activated hepatic stellate cells (HSCs) are treated with or without C-82 (3, 10 μM) for 5 days. Medium change is not performed after C-82 treatment. Cell viability is examined using XTT based Cell Proliferation Kit[1].
References	[1]. Osawa Y, et al. Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice. EBioMedicine. 2015 Oct 8;2(11):1751-8.