1253643-88-7

1253643-88-7 structure

Name: AbK
Chemical Name: H-L-Photo-lysine
CAS Number: 1253643-88-7
Molecular Formula: C₁₁H₂₀N₄O₄
Molecular Weight: 272.30
Catalog: Research Areas Others
Create Date: 2020-06-01 17:49:10
Modify Date: 2024-01-10 11:58:05
H-L-Photo-lysine is a diazirine-containing lysine amino acid and is a photo-cross-linker. H-L-Photo-lysine can site-selective incorporated into proteins and is used to crosslink protein-protein interactions in vitro and in living cells. H-L-Photo-lysine acts as a UV light-activated photo-crosslinking probe[1][2][3].

Name	H-L-Photo-lysine

Description	H-L-Photo-lysine is a diazirine-containing lysine amino acid and is a photo-cross-linker. H-L-Photo-lysine can site-selective incorporated into proteins and is used to crosslink protein-protein interactions in vitro and in living cells. H-L-Photo-lysine acts as a UV light-activated photo-crosslinking probe[1][2][3].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	Photo-lysine, which is readily incorporated into proteins by native mammalian translation machinery, can be used to capture and identify proteins that recognize lysine post-translational modifications (PTMs), including 'readers' and 'erasers' of histone modifications[2].
References	[1]. Ai HW, et al. Probing protein-protein interactions with a genetically encoded photo-crosslinking amino acid. Chembiochem. 2011 Aug 16;12(12):1854-7. [2]. Chatterjee A, et al. Efficient viral delivery system for unnatural amino acid mutagenesis in mammalian cells. Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11803-8. [3]. Yang T, et al. Photo-lysine captures proteins that bind lysine post-translational modifications. Nat Chem Biol. 2016 Feb;12(2):70-2.

Molecular Formula	C₁₁H₂₀N₄O₄
Molecular Weight	272.30