2341796-75-4

2341796-75-4 structure
2341796-75-4 structure
  • Name: (S,R,S)-AHPC-C10-NH2 dihydrochloride
  • Chemical Name: (S,R,S)-AHPC-C10-NH2 dihydrochloride
  • CAS Number: 2341796-75-4
  • Molecular Formula: C33H53Cl2N5O4S
  • Molecular Weight: 686.78
  • Catalog: Signaling Pathways PROTAC E3 Ligase Ligand-Linker Conjugate
  • Create Date: 2020-06-01 18:03:43
  • Modify Date: 2024-04-02 13:44:37
  • (S,R,S)-AHPC-C10-NH2 dihydrochloride (VH032-C10-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for BET-Targeted PROTAC[1].

Name (S,R,S)-AHPC-C10-NH2 dihydrochloride
Description (S,R,S)-AHPC-C10-NH2 dihydrochloride (VH032-C10-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for BET-Targeted PROTAC[1].
Related Catalog
Target

VHL

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. Pillow TH, et al. Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity. ChemMedChem. 2019 Oct 31.

Molecular Formula C33H53Cl2N5O4S
Molecular Weight 686.78
Storage condition 2-8°C