2240191-12-0

2240191-12-0 structure
2240191-12-0 structure
  • Name: BCR-ABL-IN-3
  • Chemical Name: BCR-ABL-IN-3
  • CAS Number: 2240191-12-0
  • Molecular Formula: C20H17ClF2N4O3S
  • Molecular Weight: 466.89
  • Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Bcr-Abl
  • Create Date: 2020-08-11 10:46:38
  • Modify Date: 2024-01-02 18:24:19
  • BCR-ABL-IN-3 is a potent and irreversible Bcr-Abl inhibitor with an IC50 of ≤100 nM for Ba/F3Bcr-AblT3151. BCR-ABL-IN-3 has anti-cancer activity[1].

Name BCR-ABL-IN-3
Description BCR-ABL-IN-3 is a potent and irreversible Bcr-Abl inhibitor with an IC50 of ≤100 nM for Ba/F3Bcr-AblT3151. BCR-ABL-IN-3 has anti-cancer activity[1].
Related Catalog
Target

Ba/F3Bcr-AblT3151:≤100 nM (IC50)

In Vivo BCR-ABL-IN-3 (compound 7; 15 mg/kg; twice a day; for 19 days) has good antitumor effect in female NOD/SCID mice of 7-8 weeks weighing 21.8 g with Ba/F3Bcr-AblT3151 cells[1]. BCR-ABL-IN-3 (2 mg/kg for IV or 20mg/kg for PO) has a Cmax of 5485 ng/mL and an AUC of 5450 h•ng/mL for IV in male Sprague Dawley rats of 7-8 weeks old weighing 210 g[1].
References

[1]. Hanyi Wang, et al. (hetero)arylamide compound for inhibiting protein kinase activity. WO2018133826A1.

Molecular Formula C20H17ClF2N4O3S
Molecular Weight 466.89