147228-80-6
147228-80-6 structure
- Name: Benzyldodecyldimethylammonium chloride dihydrate
- Chemical Name: Benzyldodecyldimethylammonium chloride dihydrate
- CAS Number: 147228-80-6
- Molecular Formula: C21H42ClNO2
- Molecular Weight: 376.02
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2020-08-10 22:25:36
- Modify Date: 2024-02-03 08:26:38
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Benzyldodecyldimethylammonium chloride dihydrate is a quaternary ammonium compound (QAC) and can be used as a biocide to target antibiotic-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), multidrug-resistant (MDR) P. aeruginosa et. al. Benzyldodecyldimethylammonium chloride dihydrate, an antimicrobial agent, bacteriostatic or bactericidal properties depending on the concentration[1][2].
| Name | Benzyldodecyldimethylammonium chloride dihydrate |
|---|---|
| Synonyms | MFCD00137276 |
| Description | Benzyldodecyldimethylammonium chloride dihydrate is a quaternary ammonium compound (QAC) and can be used as a biocide to target antibiotic-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), multidrug-resistant (MDR) P. aeruginosa et. al. Benzyldodecyldimethylammonium chloride dihydrate, an antimicrobial agent, bacteriostatic or bactericidal properties depending on the concentration[1][2]. |
|---|---|
| Related Catalog | |
| Target |
MIC: 20 mg/L (P. fluorescens)[1] |
| In Vitro | Benzyldodecyldimethylammonium chloride dihydrate (1-10 μM; 2 hours) results in a dose-dependent changes in the percent population of dead rat thymocyte cells[1]. Benzyldodecyldimethylammonium chloride dihydrate (0-40 mg/L; 0-24 hours) inhibits P. fluorescens with a MIC of 20 mg/L. At 5 mg/L, cells have the same growth behaviour as the control. At concentrations of 10 and 15 mg/L the growth profile is different from the control, and the cells start to grow only after 8 h of adaptation. At concentrations of ≥20 mg/L, BDMDAC inhibits cell growth[2]. Benzyldodecyldimethylammonium chloride dihydrate interacts strongly with cell surfaces in a concentration-dependent manner, and binds by ionic and hydrophobic interactions to microbial membrane surfaces, as manifested by phenomena such as membrane disruption and loss of membrane integrity with consequent leakage of essential intracellular constituents, which promote significant and irreversible changes in the cell structure[2]. Cell Viability Assay[1] Cell Line: Rat thymocyte cells Concentration: 0, 5, 10, 15, 20 and 40 mg/L Incubation Time: 2 hours Result: Resulted in cell death. Cell Proliferation Assay[1] Cell Line: Bacterial P. fluorescen Concentration: 0, 5, 10, 15, 20 and 40 mg/L Incubation Time: 2 hours Result: Inhibited bacterial growth in a time and dose dependent manner. |
| References |
| Melting Point | 44 °C |
|---|---|
| Molecular Formula | C21H42ClNO2 |
| Molecular Weight | 376.02 |
| Hazard Codes | Xn |
|---|---|
| RIDADR | 1759.0 |
| Hazard Class | 8.0 |