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369377-66-2

369377-66-2 structure
369377-66-2 structure
  • Name: BigLEN(rat) TFA
  • Chemical Name: BigLEN(rat)
  • CAS Number: 369377-66-2
  • Molecular Formula: C76H128N24O23
  • Molecular Weight: 1745.98
  • Catalog: Research Areas Neurological Disease
  • Create Date: 2020-08-11 09:06:26
  • Modify Date: 2024-01-10 15:25:34
  • BigLEN(rat), one of the most abundant peptides in brain, is a potent GPR171 agonist, with an EC50 of 1.6 nM[1][2].

Name BigLEN(rat)
Description BigLEN(rat), one of the most abundant peptides in brain, is a potent GPR171 agonist, with an EC50 of 1.6 nM[1][2].
Related Catalog
In Vivo BigLEN-GPR171 system plays an important role in regulating feeding and metabolism in mice[1][2].
References

[1]. Seshat M Mack, et al. Neuropeptide PEN and Its Receptor GPR83: Distribution, Signaling, and Regulation. ACS Chem Neurosci. 2019 Apr 17;10(4):1884-1891.

[2]. Ivone Gomes, et al. GPR171 Is a Hypothalamic G Protein-Coupled Receptor for BigLEN, a Neuropeptide Involved in Feeding. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16211-6.

Molecular Formula C76H128N24O23
Molecular Weight 1745.98