Shanghai Nianxing Industrial Co., Ltd
China
Product Name: CR-1-31-B
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Huang

DC Chemicals Limited
China
Product Name: CR-1-31-B
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

1352914-52-3

1352914-52-3 structure

1352914-52-3 structure

Name: CR-1-31-B
Chemical Name: CR-1-31-B
CAS Number: 1352914-52-3
Molecular Formula: C₂₈H₂₉NO₈
Molecular Weight: 507.53
Catalog: Signaling Pathways Cell Cycle/DNA Damage Eukaryotic Initiation Factor (eIF)
Create Date: 2020-08-08 15:02:19
Modify Date: 2024-01-06 20:17:20
CR-1-31-B is a potent eIF4A RNA helicase inhibitor. CR-1-31-B blocks MUC1-C translation in response to growth factor stimulation in breast cancer cells[1].

Name	CR-1-31-B

Description	CR-1-31-B is a potent eIF4A RNA helicase inhibitor. CR-1-31-B blocks MUC1-C translation in response to growth factor stimulation in breast cancer cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Eukaryotic Initiation Factor (eIF)
In Vitro	CR-1-31-B (100 nM; 24 hours) inhibits MUC1-C translation in MCF-10A cells[1]. CR-1-31-B (10 and 100 nM) decreases MUC1-C abundance in MDA-MB-468 breast cancer cells[1]. Western Blot Analysis[1] Cell Line: MCF-10A cells (EGF/HRG stimulated) Concentration: 100 nM Incubation Time: 24 hours Result: EGF-stimulated MCF-10A cells was associated with a dose-dependent decrease in MUC1-C abundance; Blocked HRG-induced increases in MUC1-C abundance.
References	[1]. Jin C, Rajabi H, Rodrigo CM, Porco JA Jr, Kufe D. Targeting the eIF4A RNA helicase blocks translation of the MUC1-C oncoprotein. Oncogene. 2013;32(17):2179-2188.

Molecular Formula	C₂₈H₂₉NO₈
Molecular Weight	507.53