2414909-94-5

2414909-94-5 structure

Name: RET V804M-IN-1
Chemical Name: RET V804M-IN-1
CAS Number: 2414909-94-5
Molecular Formula: C₁₉H₁₆N₆O
Molecular Weight: 344.37
Create Date: 2020-08-11 13:03:14
Modify Date: 2024-09-22 17:50:28
RET V804M-IN-1 (compound 5) is a wt-RET -selective inhibitors of RETV804M kinase, with an IC50 of 20 nM[1].

Name	RET V804M-IN-1

Description	RET V804M-IN-1 (compound 5) is a wt-RET -selective inhibitors of RETV804M kinase, with an IC50 of 20 nM[1].
Related Catalog	Research Areas >> Cancer
Target	IC50: 20 nM (RETV804M)[1].
In Vitro	RET V804M-IN-1 (compound 5) exhibits 3.7 and 110 fold selectivity compared to wt-RET and KDR, respectively[1].
References	[1]. Rebecca Newton, et al. Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RET V804M Kinase. ACS Med Chem Lett. 2020 Feb 28;11(4):497-505.