1619983-52-6
1619983-52-6 structure
- Name: AQX-435
- Chemical Name: AQX-435
- CAS Number: 1619983-52-6
- Molecular Formula: C27H34N2O4
- Molecular Weight: 450.57
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2021-01-09 00:01:47
- Modify Date: 2024-01-09 19:40:06
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AQX-435 is a potent SHIP1 activator. AQX-435 reduces PI3K activation downstream of the B-cell receptor (BCR) and induces apoptosis of malignant B cells, and reduces lymphoma growth[1].
| Name | AQX-435 |
|---|
| Description | AQX-435 is a potent SHIP1 activator. AQX-435 reduces PI3K activation downstream of the B-cell receptor (BCR) and induces apoptosis of malignant B cells, and reduces lymphoma growth[1]. |
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| Related Catalog | |
| In Vitro | AQX-435 reduces CLL cell viability in a dose-dependent manner[1]. AQX-435 (5-30 µM; 24 hours)-induced apoptosis was mediated via caspases since AQX435 induced PARP cleavage[1]. AQX-435 effectively inhibits PI(3,4,5)P3-mediated signaling downstream of the BCR in CLL and DLBCL cells[1]. AQX-435 and ibrutinib combine effectively to enhanced inhibition of BCR signaling. AQX-435 induced TMD8 cell apoptosis in vitro with an IC50 of ~2 µM. AQX-435 reduces anti-IgM-induced AKT phosphorylation and induces apoptosis in DLBCL cells[1]. Cell Viability Assay[1] Cell Line: Chronic lymphocytic leukemia (CLL) cells Concentration: 5-30 µM Incubation Time: 24 hours Result: Reduced CLL cell viability in a dose-dependent manner. |
| In Vivo | AQX-435 (10 mg/kg; i.p.; 5 days) significantly reduced the volume of TMD8 tumors[1]. AQX-435 (50 mg/kg; ip) inhibits DLBCL PDX tumors growth[1]. AQX-435 reduced AKT phosphorylation and growth of DLBCL in vivo and cooperated with ibrutinib for tumor growth inhibition[1]. Animal Model: NOD.Cg-Prkdc scidIl2rgtm1Wjl/SzJ mice (NSG mice) (TMD8 tumors)[1] Dosage: 10 mg/kg Administration: I.p.; in 7-day cycles each comprising 5 days of AQX-435 followed by 2 days with no drug Result: Reduced the volume of TMD8 tumors. |
| References |
[1]. Lyoyd F. MACKENZIE, et al. Ship1 modulators and methods related thereto.WO2014110036A1. |
| Molecular Formula | C27H34N2O4 |
|---|---|
| Molecular Weight | 450.57 |