925463-91-8

925463-91-8 structure

Name: Jingzhaotoxin-III
Chemical Name: Jingzhaotoxin-III
CAS Number: 925463-91-8
Molecular Formula: C₁₇₄H₂₄₁N₄₇O₄₆S₆
Molecular Weight: 3919.45
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Sodium Channel
Create Date: 2020-11-27 18:12:13
Modify Date: 2024-04-06 19:37:11
Jingzhaotoxin-III is a potent and selective blocker of Nav1.5 channels, with an IC50 of 348 nM, and shows no effect on other sodium channel isoforms. Jingzhaotoxin-III can selectively inhibit the activation of cardiac sodium channel but not neuronal subtypes, and hopefully represents an important ligand for discriminating cardiac VGSC subtype[1][2].

Name	Jingzhaotoxin-III

Description	Jingzhaotoxin-III is a potent and selective blocker of Nav1.5 channels, with an IC50 of 348 nM, and shows no effect on other sodium channel isoforms. Jingzhaotoxin-III can selectively inhibit the activation of cardiac sodium channel but not neuronal subtypes, and hopefully represents an important ligand for discriminating cardiac VGSC subtype[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease
Target	IC50: 348 nM (Nav1.5 Channels)[1]
References	[1]. Rong M, et, al. Molecular basis of the tarantula toxin jingzhaotoxin-III (β-TRTX-Cj1α) interacting with voltage sensors in sodium channel subtype Nav1.5. FASEB J. 2011 Sep; 25(9): 3177-85. [2]. Xiao Y, et, al. Jingzhaotoxin-III, a novel spider toxin inhibiting activation of voltage-gated sodium channel in rat cardiac myocytes. J Biol Chem. 2004 Jun 18; 279(25): 26220-6.

Molecular Formula	C₁₇₄H₂₄₁N₄₇O₄₆S₆
Molecular Weight	3919.45