1071001-50-7

1071001-50-7 structure

Name: GK187
Chemical Name: GK187
CAS Number: 1071001-50-7
Molecular Formula: C₁₄H₁₅F₅O₂
Molecular Weight: 310.260
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phospholipase
Create Date: 2021-01-10 11:48:33
Modify Date: 2024-01-10 05:12:09
GK187 is a potent and selective Group VIA calcium-independent phospholipase A2 (GVIA iPLA2) inhibitor with an XI(50) value of 0.0001. GK187 can be used for researching various neurological disorders[1]. [The XI(50) is the mole fraction of the inhibitor in the total substrate interface required to inhibit the enzyme by 50%.]

Name	GK187
Synonyms	3-Heptanone, 1,1,1,2,2-pentafluoro-7-(4-methoxyphenyl)- 1,1,1,2,2-Pentafluoro-7-(4-methoxyphenyl)-3-heptanone GK187

Description	GK187 is a potent and selective Group VIA calcium-independent phospholipase A2 (GVIA iPLA2) inhibitor with an XI(50) value of 0.0001. GK187 can be used for researching various neurological disorders[1]. [The XI(50) is the mole fraction of the inhibitor in the total substrate interface required to inhibit the enzyme by 50%.]
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase Research Areas >> Neurological Disease
Target	XI(50): 0.0001 (GVIA iPLA2)[1]
References	[1]. Magrioti V, et al. New potent and selective polyfluoroalkyl ketone inhibitors of GVIA calcium-independent phospholipase A2. Bioorg Med Chem. 2013 Sep 15;21(18):5823-9.