GK187

Modify Date: 2024-01-10 05:12:09

GK187 Structure
GK187 structure
Common Name GK187
CAS Number 1071001-50-7 Molecular Weight 310.260
Density 1.2±0.1 g/cm3 Boiling Point 330.3±42.0 °C at 760 mmHg
Molecular Formula C14H15F5O2 Melting Point N/A
MSDS N/A Flash Point 148.5±22.8 °C

 Use of GK187


GK187 is a potent and selective Group VIA calcium-independent phospholipase A2 (GVIA iPLA2) inhibitor with an XI(50) value of 0.0001. GK187 can be used for researching various neurological disorders[1]. [The XI(50) is the mole fraction of the inhibitor in the total substrate interface required to inhibit the enzyme by 50%.]

 Names

Name GK187
Synonym More Synonyms

 GK187 Biological Activity

Description GK187 is a potent and selective Group VIA calcium-independent phospholipase A2 (GVIA iPLA2) inhibitor with an XI(50) value of 0.0001. GK187 can be used for researching various neurological disorders[1]. [The XI(50) is the mole fraction of the inhibitor in the total substrate interface required to inhibit the enzyme by 50%.]
Related Catalog
Target

XI(50): 0.0001 (GVIA iPLA2)[1]

References

[1]. Magrioti V, et al. New potent and selective polyfluoroalkyl ketone inhibitors of GVIA calcium-independent phospholipase A2. Bioorg Med Chem. 2013 Sep 15;21(18):5823-9.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 330.3±42.0 °C at 760 mmHg
Molecular Formula C14H15F5O2
Molecular Weight 310.260
Flash Point 148.5±22.8 °C
Exact Mass 310.099213
LogP 5.32
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.438

 Synonyms

3-Heptanone, 1,1,1,2,2-pentafluoro-7-(4-methoxyphenyl)-
1,1,1,2,2-Pentafluoro-7-(4-methoxyphenyl)-3-heptanone
GK187