460331-61-7

460331-61-7 structure

Name: ML192
Chemical Name: ML-192
CAS Number: 460331-61-7
Molecular Formula: C₂₀H₂₂N₄O₂S
Molecular Weight: 382.479
Catalog: Signaling Pathways Epigenetics PKC
Create Date: 2021-08-27 18:33:44
Modify Date: 2024-07-18 10:38:47
ML192 is a selective ligand antagonist of GPR55. ML192 inhibits the β-arrestin trafficking, ERK1/2 phosphorylation and PKCβII translocation[1].

Name	ML-192
Synonyms	2-furanyl-[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]methanone Furan-2-yl-[4-(2-methyl-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-piperazin-1-yl]-methanone ML-192 2-Furyl[4-(2-methyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl)-1-piperazinyl]methanone Methanone, 2-furanyl[4-(5,6,7,8-tetrahydro-2-methyl[1]benzothieno[2,3-d]pyrimidin-4-yl)-1-piperazinyl]-

Description	ML192 is a selective ligand antagonist of GPR55. ML192 inhibits the β-arrestin trafficking, ERK1/2 phosphorylation and PKCβII translocation[1].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> GPR55 Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> TGF-beta/Smad >> PKC Signaling Pathways >> Stem Cell/Wnt >> ERK
Target	ERK2 ERK1 PKCβII
In Vitro	ML192 抑制 10 μM L-α 溶血磷脂酰肌醇 (LPI) 或 1 μM ML186 诱导的 β-arrestin 转运，IC50 值分别为0.70μM、0.29 µM[1]。 ML192 显著抑制表达 GPRSS 的 U2OS 细胞中 ERK1/2 的磷酸化[1]。 ML192 (0, 10, 30 和 100 µM) 减弱了野生型 GPR55 受体细胞中的 PKCβII 易位[1]。
References	[1]. Kotsikorou E, et al. Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry. 2013 Dec 31;52(52):9456-69.