2384184-40-9
2384184-40-9 structure
- Name: KB02-SLF
- Chemical Name: KB02-SLF
- CAS Number: 2384184-40-9
- Molecular Formula: C50H65ClN4O12
- Molecular Weight: 949.52
- Create Date: 2021-01-06 21:29:14
- Modify Date: 2023-02-03 11:34:12
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KB02-SLF is a PROTAC-based nuclear FKBP12 degrader (molecular glue). KB02-SLF promotes nuclear FKBP12 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems. SLF binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-SLF.
| Name | KB02-SLF |
|---|
| Description | KB02-SLF is a PROTAC-based nuclear FKBP12 degrader (molecular glue). KB02-SLF promotes nuclear FKBP12 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems. SLF binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-SLF. |
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| Molecular Formula | C50H65ClN4O12 |
|---|---|
| Molecular Weight | 949.52 |
| Hazard Codes | Xi |
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