1177767-57-5

1177767-57-5 structure
1177767-57-5 structure
  • Name: Desmethyl-YM 298198
  • Chemical Name: Desmethyl-YM 298198
  • CAS Number: 1177767-57-5
  • Molecular Formula: C17H21ClN4OS
  • Molecular Weight: 364.89
  • Catalog: Signaling Pathways GPCR/G Protein mGluR
  • Create Date: 2021-05-02 18:53:04
  • Modify Date: 2024-04-06 22:06:56
  • Desmethyl-YM-298198 hydrochloride is a high-affinity, selective, and noncompetitive mGluR1 antagonist (IC50: 16 nM). Desmethyl-YM-298198 hydrochloride has analgesic effect in Streptozotocin (HY-13753)-induced hyperalgesic mice[1].

Name Desmethyl-YM 298198
Synonyms MFCD08458897
6-Amino-N-cyclohexyl-3-methyl[1,3]thiazolo[3,2-a]benzimidazole-2-carboxamide hydrochloride (1:1)
Thiazolo[3,2-a]benzimidazole-2-carboxamide, 6-amino-N-cyclohexyl-3-methyl-, hydrochloride (1:1)
Description Desmethyl-YM-298198 hydrochloride is a high-affinity, selective, and noncompetitive mGluR1 antagonist (IC50: 16 nM). Desmethyl-YM-298198 hydrochloride has analgesic effect in Streptozotocin (HY-13753)-induced hyperalgesic mice[1].
Related Catalog
Target

16 nM (mGluR1)[1]

References

[1]. Kohara A, et al. Radioligand binding properties and pharmacological characterization of 6-amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide (YM-298198), a high-affinity, selective, and noncompetitive antagonist of metabotropic glutamate receptor type 1. J Pharmacol Exp Ther. 2005 Oct;315(1):163-9.  

Molecular Formula C17H21ClN4OS
Molecular Weight 364.89
Exact Mass 364.112457