159533-25-2

159533-25-2 structure

Name: GR 55562 dihydrochloride
Chemical Name: GR 55562 dihydrochloride
CAS Number: 159533-25-2
Molecular Formula: C₂₃H₂₇Cl₂N₃O₂
Molecular Weight: 448.39
Create Date: 2021-05-09 11:57:56
Modify Date: 2024-01-28 20:29:32
GR 55562 (dihydrochloride) is a selective 5-HT1B receptor antagonist. GR 55562 can be used for the research of nerve disease[1].

Name	GR 55562 dihydrochloride
Synonyms	3-[3-(Dimethylamino)propyl]-4-hydroxy-N-[4-(pyridin-4-yl)phenyl]benzamide dihydrochloride 3-[3-(Dimethylamino)propyl]-4-hydroxy-N-[4-(4-pyridinyl)phenyl]benzamide dihydrochloride Benzamide, 3-[3-(dimethylamino)propyl]-4-hydroxy-N-[4-(4-pyridinyl)phenyl]-, hydrochloride (1:2) MFCD06201848 MFCD01861177

Description	GR 55562 (dihydrochloride) is a selective 5-HT1B receptor antagonist. GR 55562 can be used for the research of nerve disease[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
In Vivo	GR 55562 (0.1-10 μg/side) 进入伏隔子区域不会引起cocaine杠杆响应[1]。 GR 55562 (0.1-10 μg/side)（伏核壳或核中）的未能调节cocaine（5 mg/kg）的辨别作用[1]。 GR 55562 (1 μg/side) 显着减弱了对cocaine的辨别作用[1]。 Animal Model: Male Wistar rats (280-300 g; n=50)[1]. Dosage: 0.1-10 μg/side Administration: Injected intracranially; At a volume of 0.2 µl/side Result: Did not evoke substitution for the drug with intra-accumbal shell infusion. Did not significantly affect the discriminative stimulus effects produced by 5 mg/kg of cocaine. GR 55562 (1 µg/side) attenuated the enhancement of cocaine discrimination evoked by a combination of intra-accumbal core CP 93129 (1 µg/side) and systemic cocaine (1.25 mg/ kg or 2.5 mg/kg).
References	[1]. Filip M, et al. Effects of serotonin (5-HT)(1B) receptor ligands, microinjected into accumbens subregions, on cocaine discrimination in rats. Naunyn Schmiedebergs Arch Pharmacol. 2002;366(3):226-234.