885104-09-6

885104-09-6 structure

Name: LY2389575 hydrochloride
Chemical Name: LY 2389575 hydrochloride
CAS Number: 885104-09-6
Molecular Formula: C₁₅H₁₆BrCl₃N₄
Molecular Weight: 438.58
Create Date: 2021-05-16 11:31:58
Modify Date: 2024-01-22 15:56:51
LY2389575 hydrochloride is a selective and noncompetitive mGlu3 negative allosteric modulator (NAM), with an IC50 value of 190 nM. LY2389575 hydrochloride induces an increase in Mrc1 levels. LY2389575 hydrochloride also independently amplifies Amyloid beta (Aβ) toxicity and can be used in study of Alzheimer's disease[1][2][3].

Name	LY 2389575 hydrochloride
Synonyms	3-Pyrrolidinamine, 1-(5-bromo-2-pyrimidinyl)-N-[(2,4-dichlorophenyl)methyl]-, (3S)-, hydrochloride (1:1) (3S)-1-(5-Bromo-2-pyrimidinyl)-N-(2,4-dichlorobenzyl)-3-pyrrolidinamine hydrochloride (1:1) MFCD28133385

Description	LY2389575 hydrochloride is a selective and noncompetitive mGlu3 negative allosteric modulator (NAM), with an IC50 value of 190 nM. LY2389575 hydrochloride induces an increase in Mrc1 levels. LY2389575 hydrochloride also independently amplifies Amyloid beta (Aβ) toxicity and can be used in study of Alzheimer's disease[1][2][3].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
Target	mGluR3:190 nM (IC50)
In Vitro	LY2389575 hydrochloride (5 μM; 1 h) 诱导小胶质细胞中 Mrc1 的水平升高[2]。 Real Time qPCR[2] Cell Line: Microglial cells Concentration: 5 μM Incubation Time: 1 h Result: Increased levels of Mrc1.
References	[1]. Caraci F, et al. Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective. Mol Pharmacol. 2011 Mar;79(3):618-26. [2]. Zinni M, et al. mGlu3 receptor regulates microglial cell reactivity in neonatal rats. J Neuroinflammation. 2021 Jan 6;18(1):13. [3]. Srivastava A, et al. Metabotropic Glutamate Receptors in Alzheimer's Disease Synaptic Dysfunction: Therapeutic Opportunities and Hope for the Future. J Alzheimers Dis. 2020;78(4):1345-1361.

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