1331635-21-2

1331635-21-2 structure

Name: Olopatadine-d3 (hydrochloride)
Chemical Name: Olopatadine-d3 (hydrochloride)
CAS Number: 1331635-21-2
Molecular Formula: C₂₁H₂₁D₃ClNO₃
Molecular Weight: 376.892
Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
Create Date: 2021-05-04 21:47:50
Modify Date: 2024-01-16 15:01:08
Olopatadine-d3 hydrochloride (ALO4943A-d3) is the deuterium labeled Olopatadine hydrochloride. Olopatadine hydrochloride (ALO4943A) is a histamine blocker used to treat allergic conjunctivitis[1][2].

Name	Olopatadine-d3 (hydrochloride)
Synonyms	Olopatadine-d3 (hydrochloride) Dibenz[b,e]oxepin-2-acetic acid, 6,11-dihydro-11-[3-(methylmethyl-d3-amino)propylidene]-, (11E)-, hydrochloride (1:1) [(11E)-11-(3-{Methyl[(2H3)methyl]amino}propylidene)-6,11-dihydrodibenzo[b,e]oxepin-2-yl]acetic acid hydrochloride (1:1)

Description	Olopatadine-d3 hydrochloride (ALO4943A-d3) is the deuterium labeled Olopatadine hydrochloride. Olopatadine hydrochloride (ALO4943A) is a histamine blocker used to treat allergic conjunctivitis[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Endocrinology Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Tamura, T., et al., Effect of olopatadine and other histamine H1 receptor antagonists on the skin inflammation induced by repeated topical application of oxazolone in mice. Pharmacology, 2005. 75(1): p. 45-52. [3]. Ohmori, K., et al., Pharmacological, pharmacokinetic and clinical properties of olopatadine hydrochloride, a new antiallergic drug. Jpn J Pharmacol, 2002. 88(4): p. 379-97. [4]. Yanni, J.M., et al., The in vitro and in vivo ocular pharmacology of olopatadine (AL-4943A), an effective anti-allergic/antihistaminic agent. J Ocul Pharmacol Ther, 1996. 12(4): p. 389-400.